Zeiss LSM 880

Our microscopy facility features cutting-edge confocal laser scanning microscopes with Airyscan from Zeiss. Our goal is to advance the research of the Boston community by offering competitive pricing and expertise.

Application Forms

Zeiss LSM 880

Instrument Snapshot

This confocal laser scanning microscope’s lasers are designed for deeper imaging of fixed tissue samples and live animals with high sensitivity.  Paired with Airyscan module, images are 1.7 higher in resolution and sensitivity than compared to other scopes of this type.

With a large field of view and high image-acquisition speed, the microscope is able to identify and localize molecules of interest and their interactions in space and time while minimizing the input of light.

Reach out to our core facility in Boston with any questions at cils-core@northeastern.edu.



Laser line: 405, 488, 514, 561, 594, 640 nm


Objective: 10×20×40×40×63×


Cage incubator, CO2/O2 Control


Spectral Unmixing

Sample Images

Axolotl Limb Regeneration

Instrument: Zeiss LSM 880
Technique: FISH – Uromodulin(yellow), keratin 5 (cyan)-, Wnt5a (magenta)
Credit: Alex Lovely/Monaghan Lab

Mouse Tissue Section

Instrument: Zeiss LSM 880 with Airyscan Fast
HCR-FISH image at postnatal day 18
Credit: Rachel Pierce/Ionescu Lab

Bovine Pulmonary Artery Endothelial Cell

Instrument: Zeiss LSM 880 using Airyscan
Stained for nuclei (blue), tubulin (red), and phalloidin (green)
Credit: Alex Lovely/CILS Institute


Internal NU


External Academia




Additional Resources

Carl Zeiss Microscopy Online Campus

Education in Microscopy and Digital Imaging

LSM 880 Operating Manual

Detailed guide to LSM 880

Nature Methods:

The Fast mode for ZEISS LSM 880 with Airyscan: high-speed confocal imaging with super-resolution and improved signal-to-noise ratio

Other Instruments

Zeiss LSM 800 (Inverted)

NU user: $30/hr; Academia: $50/hr; Industry: $70/hr

Laser line: 405, 488, 561, 640nm

Objective: 10×20×40×63×

Fixed cell/tissue imaging

Imaging Tiling


Zeiss LSM 880 NLO (Upright)

NU user: $50/hr; Academia: $70/hr; Industry: $90/hr

Laser line: 405, 458, 488, 514, 561, 594, 640 nm

NIR Laser: tunable line (680-1300 nm); fixed line -1045 nm

Objective: 10×20×20×, 40×20×-CLARITY

Multi-photon imaging

Superresolution (Airyscan)

Spectral Unmixing

Prerequisite: Bioraft Laser Safety Training Part I and II

Zeiss Light Sheet Z1

NU user: $50/hr; Academia: $70/hr; Industry: $90/hr

Laser line: 405, 488, 561, 638 nm

Objective: 5×, 10×-water20×-CLARITY

CO2/temperature control

Large scale 3D tissue imaging

arivis Vision4D software

Our facility

Interdisciplinary Science and Engineering Complex

ISEC 080, 805 Columbus Ave, Boston, MA, 02115