CILS Member Ke Zhang is researching a new drug delivery method using oligonucleotides to treat Duchenne Muscular Dystrophy (DMD), with potential applications in other genetic diseases, offering hope for more efficient treatments.
Our researchers collaborate across five following core disciplines to develop breakthrough imaging tools:
- Probe Development
- Probe Delivery
- Imaging Technologies
- Animal Models
- Signal Processing
Chemical analysis could be used to study processes like neurotransmitter release, but the field currently has a scale problem. New technologies are needed that can balance the specificity of cellular imaging with the functional, structural, or spatial capabilities of whole-body imaging.
Manuscripts enabled by CILS core facilities
Our goal is to create a new suite of modular nanoscale tools, probes that image dynamic biological processes beyond what is currently feasible. By forming multidisciplinary teams, we select and focus on a difficult problem that needs a solution – the interface between instrumentation and the biological environment is key to our success. Starting from a research question, we work through the probe’s lifecycle, from novel platform development, continuing through to its biological application.
Enabling a doctor to measure specific biomolecules in a patient over disease progression will lead to better-informed diagnostics and personalized care.
Animal models better reflect a specific neurological disease state, and the same tools used to study these models can be used to further human research.
Diseases can be studied in a highly personalized fashion, for the design and development of precision interventions.
Tissue Clearing Webinar
Come join us on February 10th, 2023 at 1-2 pm (EST)📅 to learn more about how to improve your microscopy images of thick samples via Tissue Clearing 🔬
Our imaging scientist Eun will explain why tissue clearing is important to boost microscopy signal from your thick samples, and will discuss different methods and applications.
Register here: ➡ https://lnkd.in/ey5eg9y2 ⬅
CILS member and bioengineering professor Mark Niedre was awarded a $2.7M grant for 5 years along with co-PI Chiara Bellini. The grant project is titled "Continuous, Non-Invasive Optical Monitoring of Circulating Tumor Cell-Mediated Metastasis in Awake Mice".