Our researchers collaborate across five following core disciplines to develop breakthrough imaging tools:
- Probe Development
- Probe Delivery
- Imaging Technologies
- Animal Models
- Signal Processing
The development of novel imaging tools for real-time detection of molecular neural events, such as neurotransmitter release, is fundamental for studying the basis of brain function and disease, which leads to the development of better diagnostics and therapeutics.
Chemical analysis could be used to study processes like neurotransmitter release, but the field currently has a scale problem. New technologies are needed that can balance the specificity of cellular imaging with the functional, structural, or spatial capabilities of whole-body imaging.
Manuscripts enabled by CILS core facilities
Our goal is to create a new suite of modular nanoscale tools, probes that image dynamic biological processes beyond what is currently feasible. By forming multidisciplinary teams, we select and focus on a difficult problem that needs a solution – the interface between instrumentation and the biological environment is key to our success. Starting from a research question, we work through the probe’s lifecycle, from novel platform development, continuing through to its biological application.
Enabling a doctor to measure specific biomolecules in a patient over disease progression will lead to better-informed diagnostics and personalized care.
Animal models better reflect a specific neurological disease state, and the same tools used to study these models can be used to further human research.
Diseases can be studied in a highly personalized fashion, for the design and development of precision interventions.
We have demonstrated new nanoscale probes to detect in vivo analytes such as glucose (with applications for diabetes), electrolytes (relevant for dehydration for endurance sports and military applications), therapeutic drug monitoring, neurotransmitters (useful for neurodegenerative disease) and cytokines (to detect immune response in COVID-19).
CILS Seminar: Flow Cytometry
Join us for an information session on the features of our Beckman cell sorter and analyzer. During the seminar, participants will hear from users about their experiences and applications for a variety of projects, followed by a student presentation.
September 28th, 2021 12-1:30pm
New Nanosensor Holds Promise for Diagnosing, Treating Neurological Disease
Heather Clark, James Monaghan
CILS founders developed a DNA-based nanosensor that detects a specific neurotransmitter, acetylcholine, as it’s released and picked up by target cells in living animals.