Getting Started at the Core Facility

From research concept to hands-on bioimaging

A Step-by-Step Guide to Accessing the Core Facility

Project Meeting

  • Meet with Core staff
  • Discuss experience level, experiment logistics, and project goals

Pre-Training

  • User and PI complete intake forms
  • User completes relevant Biosafety Trainings

 

Training Session I

  • Core staff demonstrates usage on relveant instrument using training sample or user-provided sample

Training Session II

  • User demonstrates usage on relevant instrument under supervision of Core staff

Post-Training

  • After observation of satisfactory usage, user gains booking and facility access

Set Up a Project Meeting

Instrument(s) of Interest

15 + 4 =

Our facility

Interdisciplinary Science and Engineering Complex

ISEC 080, 805 Columbus Ave, Boston, MA, 02115

FY2024

Mild repetitive TBI reduces brain-derived neurotrophic factor (BDNF) in the substantia nigra and hippocampus: A preclinical model for testing BDNF-targeted therapeutics
Wooden Steps to Shallow Depths: A New Bathymodiolin Mussel, Vadumodiolus teredinicola, Inhabits Shipworm Burrows in an Ancient Submarine Forest
Milk Exosomes Anchored with Hydrophilic and Zwitterionic Motifs Enhance Mucus Permeability for Applications in Oral Gene Delivery
Engineered Bacteria Titrate Hydrogen Sulfide and Induce Concentration-Dependent Effects on Host in a Gut Microphysiological System
Endothelial Glycocalyx Sensitivity to Chemical and Mechanical Sub-Endothelial Substrate Properties
Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions
Hypoxia-Inducing Cryogels Uncover Key Cancer-Immune Cell Interactions in An Oxygen-Deficient Tumor Microenvironment
Direct Differentiation of Human Pluripotent Stem Cells into Vascular Network along with Supporting Mural Cells

FY2023

Bioengineered Perfused Human Brain Microvascular Networks Enhance Neural Progenitor Cell Survival, Neurogenesis, And Maturation
Pten, Pi3K and PtdIns(3,4,5)P3 Dynamics Modulate Pulsatile Actin Branching in Drosophila Retina Morphogenesis
Medioapical Contractile Pulses Coordinated between Cells Regulate Drosophila Eye Morphogenesis
Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis
Sox17 Mediates Adult Arterial Endothelial Cell Response to Hemodynamics
Cold Exposure Impairs Extracellular Vesicle Swarm–Mediated Nasal Antiviral Immunity
Lineage-Mismatched Mitochondrial Replacement in an Inducible Mitochondrial Depletion Model Effectively Restores the Original Proteomic Landscape of Recipient Cells
Exploring Functional Protein Covariation across Single Cells Using nPOP
Transport of Symbiont-Encoded Cellulases from the Gill to the Gut of Shipworms via the Enigmatic Ducts of Deshayes: A 174-Year Mystery Solved
Click Chemistry-Enabled Conjugation Strategy for Producing Dibenzodiazepinone-Type Fluorescent Probes To Target M2 Acetylcholine Receptors
Developing a Transwell Millifluidic Device for Studying Blood-Brain Barrier Endothelium
Diosmin and Its Glycocalyx Restorative and Anti‐Inflammatory Effects on Injured Blood Vessels
pH-Responsive i-motif-Conjugated Nanoparticles for MRI Analysis
Hybridization Chain Reaction Fluorescence In Situ Hybridization (HCR-FISH) in Ambystoma mexicanum Tissue
Intra-Articular Kinetics of a Cartilage Targeting Cationic PEGylated Protein for Applications in Drug Delivery
Charge-Based Drug Delivery to Cartilage: Hydrophobic and not Electrostatic Interactions are the Dominant Cause of Competitive Binding of Cationic Carriers in Synovial fluid
In vitro Testbed Platform for Evaluating Small Volume Contrast Agents via Magnetic Resonance Imaging
Usability of Deep Learning Pipelines for 3D Nuclei Identification with Stardist and Cellpose
A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes
Hypoxia Inhibits the Cardiac IK1 Current through SUMO Targeting Kir2.1 Activation by PIP2
Denoising Multiplexed Microscopy Images in N-Dimensional Spectral Space
Cationic Peptide Carriers Enable Long Term Delivery of Insulin-Like Growth Factor-1 to Suppress Osteoarthritis-Induced Matrix Degradation
Increasing the Throughput of Sensitive Proteomics by plexDIA
Targeting Oncogenic KRAS with Molecular Brush-Conjugated Antisense Oligonucleotides

FY2022

Local Mechanical Stimuli Correlate with Tissue Growth in Axolotl Salamander Joint Morphogenesis
Maximizing TLR9 Activation in Cancer Immunotherapy with Dual-Adjuvanted Spherical Nucleic Acids
Single-Dose Intra-Cartilage Delivery of Kartogenin Using a Cationic Multi-Arm Avidin Nanocarrier Suppresses Cytokine-Induced Osteoarthritis-Related Catabolism
Regenerating Axolotl Retinas Regrow Diverse Cell Types with Modulation by Notch Signaling and Reconnect to the Brain
Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration
A Constitutively Expressed Fluorescence Ubiquitination-Based Cell Cycle Indicator (FUCCI) in Axolotls for Studying Tissue Regeneration
Development of Fluorescently Labeled, Functional Type I Collagen Molecules
Interstitial Flow Enhances the Formation, Connectivity, and Function of 3D Brain Microvascular Networks Generated within a Microfluidic Device
Regeneration and Assessment of the Endothelial Glycocalyx To Address Cardiovascular Disease
Mild Repetitive Head Impacts Alter Perivascular Flow in the Midbrain Dopaminergic System in Awake Rats
Quantitative Imaging of Blood-Brain Barrier Permeability Following Repetitive Mild Head Impacts
High-Throughput Microfluidic 3D Biomimetic Model Enabling Quantitative Description of the Human Breast Tumor Microenvironment
Injectable Lignin-co-Gelatin Cryogels with Antioxidant and Antibacterial Properties for Biomedical Applications
Mechanical Causation of Biological Structure: Productive Pulls Produce Persistent Filaments in a Human Fibroblast Model of Matrix Development
Bottlebrush Polymer-Conjugated Melittin Exhibits Enhanced Antitumor Activity and Better Safety Profile
Two-Photon Peak Molecular Brightness Spectra Reveal Long-Wavelength Enhancements of Multiplexed Imaging Depth and Photostability

FY2021

Stiffening of the Extracellular Matrix is a Sufficient Condition for Airway Hyperreactivity
Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID-19 Vaccines
Imaging in vivo Acetylcholine Release in the Peripheral Nervous System with a Fluorescent Nanosensor
A DNA-Based MRI Contrast Agent for Quantitative pH Measurement
Confocal Imaging Capacity on a Widefield Microscope Using a Spatial Light Modulator
Lung Injury in Axolotl Salamanders Induces an Organ‐Wide Proliferation Response
3D Visualization of Macromolecule Synthesis
Self-Assembled DNA–PEG Bottlebrushes Enhance Antisense Activity and Pharmacokinetics of Oligonucleotides

FY2020

High-Power Light-Emitting Diode Array Design and Assembly for Practical Photodynamic Therapy Research
Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies
Optical Nanosensors for in vivo Physiological Chloride Detection for Monitoring Cystic Fibrosis Treatment
Site‐Specific Bioconjugation and Convergent Click Chemistry Enhances Antibody–Chromophore Conjugate Binding Efficiency
Real-Time Particle-by-Particle Detection of Erythrocyte-Camouflaged Microsensor with Extended Circulation Time in the Bloodstream
Multichannel Correlation Improves the Noise Tolerance of Real-Time Hyperspectral Microimage Mosaicking